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J R Soc Med 1982;75:408-413
© 1982 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 75, Issue 6 408-413, Copyright © 1982 by Royal Society of Medicine

ORIGINAL ARTICLES

Results of surgery in 88 consecutive cases of extrahepatic biliary atresia

ER Howard, M Driver, J McClement and AP Mowat

Of 88 cases of extrahepatic biliary atresia, satisfactory bile flow has been established in 46% of the patients who have undergone portoenterostomies and in 25% of patients with hepaticojejunostomies. Histological analysis of the extrahepatic biliary tissue has not shown a consistent correlation with outcome of operation, except that the patients with one or two large residual ducts lined with columnar epithelium have a better chance of developing bile flow. Cholangitis developed in 43% of the cases, and co-trimoxazole was not shown to have any beneficial effect in a small prospective trial in 18 patients. Severe haemorrhage from oesophageal varices has occurred in 4 jaundice-free survivors. Seventeen patients are now over 3 years of age and thriving but many show persistent elevation of liver enzymes.
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