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J R Soc Med 1985;78:230-233
© 1985 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 78, Issue 3 230-233, Copyright © 1985 by Royal Society of Medicine

ORIGINAL ARTICLES

Protective role of faecal pH in experimental colon carcinogenesis

SL Samelson, RL Nelson and LM Nyhus

There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
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