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J R Soc Med 1985;78:291-293
© 1985 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 78, Issue 4 291-293, Copyright © 1985 by Royal Society of Medicine

ORIGINAL ARTICLES

Long-term follow up of trans-sphenoidal hypophysectomy for Cushing's disease

IR Brand, GA Dalton and RF Fletcher

Fourteen patients with Cushing's disease treated by trans-sphenoidal hypophysectomy between 1962 and 1975 were reviewed in 1983. Complete ablation had been attempted. There were no surgical deaths and one episode of bacterial meningitis. Two patients required a second operation for a cerebrospinal fluid leak. There have been three late deaths from unrelated causes. All patients had a biochemical remission of their Cushing's disease postoperatively and no relapse has been recorded. Most patients need some hormone replacement but residual pituitary function and sella radiography have remained stable. This treatment seems satisfactory and the evidence implies a pituitary aetiology of the syndrome.
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