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J R Soc Med 1985;78:459-462
© 1985 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 78, Issue 6 459-462, Copyright © 1985 by Royal Society of Medicine


ORIGINAL ARTICLES

Effects on upper gastrointestinal mucosa of three delivery systems of potassium as supplement to frusemide administration

JC McLoughlin

Thirty healthy volunteers were recruited into a study to determine the effects on the gastrointestinal mucosa of 3 different delivery systems of oral potassium supplementation associated with diuretic therapy (Diumide-K ContinusR tablets, Napp; Lasikal tablets, Hoechst; Lasix and Slow-KR tablets, Hoechst, Ciba). The volunteers were gastroscoped initially and after one week of treatment with one of the three therapies. There was a 60% incidence of erosions in the Lasix + Slow-K group, a 40% incidence in the Lasikal group, but no erosions in the group receiving Diumide-K Continus tablets. It is therefore concluded that Diumide-K Continus tablets incorporate the potassium in a delivery system which is unlikely to cause disruption to the gastrointestinal mucosa.
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