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J R Soc Med 1986;79:15-16
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 1 15-16, Copyright © 1986 by Royal Society of Medicine

ORIGINAL ARTICLES

Three times daily or 8-hourly

R Nigam, BJ Loveday, SL Grainger and DG Maxton

The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.
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