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J R Soc Med 1986;79:19-21
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 1 19-21, Copyright © 1986 by Royal Society of Medicine

ORIGINAL ARTICLES

Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study

MG Salem and RS Ahearn

One hundred and fifteen patients, separated into 4 groups, received neostigmine 5 mg with either atropine 1.2 mg or 1.8 mg, or glycopyrrolate 0.6 mg or 0.9 mg. Those receiving 0.9 mg glycopyrrolate had insignificant changes in heart rate in the immediate postreversal period. It is recommended that when glycopyrrolate is used with 5 mg neostigmine, the optimum dose is 0.9 mg.
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