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J R Soc Med 1986;79:584-587
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 10 584-587, Copyright © 1986 by Royal Society of Medicine


ORIGINAL ARTICLES

Does dimethicone increase the efficacy of antacids in the treatment of reflux oesophagitis?

AL Ogilvie and M Atkinson

Dimethicone is a common additive to antacids, although its value in the treatment of reflux oesophagitis is unproven. Its efficacy was assessed by comparing the effect of a dimethicone-containing antacid gel (Asilone Gel) with a simple antacid gel in a double-blind trial in 45 patients with reflux oesophagitis. Thirty-eight patients completed the eight-week course of therapy. Antacid therapy alone resulted in a significant improvement of both symptoms and oesophagitis in gastro-oesophageal reflux. The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms of symptomatic assessment but did confer a small advantage with regard to objective markers of oesophageal inflammation, suggesting that a dimethicone-containing antacid is of value in the treatment of symptomatic gastro-oesophageal reflux.
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Arch Intern MedHome page
L. I. Kitchin and D. O. Castell
Rationale and Efficacy of Conservative Therapy for Gastroesophageal Reflux Disease
Arch Intern Med, March 1, 1991; 151(3): 448 - 454.
[Abstract] [PDF]



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