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J R Soc Med 1986;79:137-141
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 3 137-141, Copyright © 1986 by Royal Society of Medicine

ORIGINAL ARTICLES

Single-dose antibiotic prophylaxis of abdominal surgical wound infection: a trial of preoperative latamoxef against peroperative tetracycline lavage

P Sauven, MJ Playforth, GM Smith, M Evans and AV Pollock

A randomized controlled clinical trial was undertaken in 542 consecutive emergency and elective abdominal operations, with one group of patients receiving tetracycline peritoneal and wound lavage and the other a single intravenous injection of 1 g latamoxef at induction of anaesthesia. Seventy-five patients were withdrawn because no potentially contaminated hollow viscus was opened, and a further 36 because they could not be assessed for wound infection. Of the remaining 431 patients, 212 received latamoxef resulting in 5 major and 8 minor wound infections in hospital; another 4 minor infections occurred at home (total incidence 8.0%). In the tetracycline group (n = 219) there were 7 major and 19 minor wound infections in hospital and 10 minor infections later (total incidence 16.4%). This is significantly higher than the rate with latamoxef (P = 0.012). Monitoring of operative and postoperative bleeding revealed no evidence (except in one doubtful case) of excessive bleeding associated with the use of a single dose of latamoxef. It is concluded that single-dose preoperative latamoxef is more effective than peroperative tetracycline lavage for the prevention of wound infections after potentially contaminated abdominal operations.
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This article has been cited by other articles:


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M. Schein, G. Gecelter, W. Freinkel, H. Gerding, and P. J. Becker
Peritoneal Lavage in Abdominal Sepsis: A Controlled Clinical Study
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[Abstract] [PDF]

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J. C. Hall, J. McK. Watts, L. Press, P. O'Brien, J. Turnidge, and P. McDonald
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