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J R Soc Med 1986;79:451-453
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 8 451-453, Copyright © 1986 by Royal Society of Medicine

ORIGINAL ARTICLES

Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome

DJ Evans and CW Burke

Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.
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