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J R Soc Med 1986;79:510-514
© 1986 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 79, Issue 9 510-514, Copyright © 1986 by Royal Society of Medicine

ORIGINAL ARTICLES

Kaposi's sarcoma and HTLV-III: a study in Nigerian adult males

AA Otu

Sera from 37 adult Nigerian men with Kaposi's sarcoma (KS), 30 contemporaneous controls bearing primary cell carcinoma of the liver (PCL), and 150 healthy non-tumour-bearing negative controls were tested for antibody to human T-cell lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) by enzyme-linked immunosorbent assays (ELISA). Certain immunocellular functions were also measured: the chemotactic locomotion of peripheral blood monocytes towards casein, delayed-type cutaneous hypersensitivity reaction to tuberculoprotein and opportunistic infection with the fungus Candida albicans. Sera from all these groups were also tested for markers of previous infections with the viruses cytomegalovirus (CMV), Epstein-Barr virus (EBV), hepatitis B (HBV) and hepatitis A (HAV). All serum samples tested were reproducibly and consistently negative for anti-HTLV-III/LAV. Peripheral blood monocytes from both KS and PCL patients showed profound depression of chemotaxis; similarly all tumour patients gave markedly depressed cutaneous reactivity to tuberculoprotein and uniformly exhibited seropositivity to CMV, EBV, HBV and HAV. A great majority showed evidence of infection with Candida albicans. It is concluded that tropical African KS is not associated with HTLV-III/LAV infection.
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K. C. Iregbu and O. Y. Elegba
Prevalence of Kaposi's Sarcoma Among Adult HIV-Seropositive Patients Seen in a Designated HIV Treatment and Care Center in Abuja, Nigeria
J Int Assoc Physicians AIDS Care (Chic Ill), September 1, 2006; 5(3): 115 - 118.
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