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J R Soc Med 1989;82:93-94
© 1989 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 82, Issue 2 93-94, Copyright © 1989 by Royal Society of Medicine

ORIGINAL ARTICLES

The reduction of low density lipoprotein cholesterol by metformin is maintained with long-term therapy

SG Rains, GA Wilson, W Richmond and RS Elkeles
Department of Endocrinology, St Mary's Hospital, London.

Changes in serum lipoproteins were studied in 14 non-insulin dependent diabetics on long-term metformin therapy, after 6 weeks' placebo, and again 6 weeks after restarting active drug therapy. Withdrawal of metformin resulted in a rise of fasting blood glucose, HbA1, serum total and low density lipoprotein (LDL) cholesterol. Restarting the drug reversed these changes. Multivariate analysis showed that serum total and LDL cholesterol varied with treatment but not with glycaemic control. Metformin can lower serum total and LDL cholesterol in non-insulin dependent diabetics and this effect is maintained long term.
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This article has been cited by other articles:


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 Arch Intern MedHome page
S. R. Salpeter, E. Greyber, G. A. Pasternak, and E. E. Salpeter
Risk of Fatal and Nonfatal Lactic Acidosis With Metformin Use in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis
Arch Intern Med, November 24, 2003; 163(21): 2594 - 2602.
[Abstract] [Full Text] [PDF]


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