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J R Soc Med 1989;82:479-483
© 1989 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 82, Issue 8 479-483, Copyright © 1989 by Royal Society of Medicine

ORIGINAL ARTICLES

Hyponatraemia and Moduretic-grand mal seizures: a review

C Johnston, L Webb, J Daley and GS Spathis
Department of Medicine, St Helier Hospital, Carshalton, Surrey.

Three cases are presented which emphasize the importance of hyponatraemia as a cause of grand mal seizures. The combination of hydrochlorothiazide and amiloride appears to increase the risk of hyponatraemia. We discuss the aetiology and treatment of hyponatraemia and review the necessity for such combination therapy. We recommend caution in prescribing diuretics and preparations such as Moduretic should be used only in those few patients shown to need potassium supplementation.
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