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J R Soc Med 1996;89:47-48
© 1996 Royal Society of Medicine

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Journal of the Royal Society of Medicine, Vol 89, Issue 1 47-48, Copyright © 1996 by Royal Society of Medicine

ORIGINAL ARTICLES

ANCA associated with Behcet's disease

NP Burrows, MH Zhao, PG Norris and CM Lockwood
Department of Dermatology, Addenbrooke's Hospital Cambridge, England.

Behcet's disease is a multisystem disorder affecting primarily mucocutaneous and ocular sites although the gastrointestinal, cardiovascular, central nervous and respiratory systems may also be involved. Hulusi Behcet, a Turkish dermatologist, first described Behcet's disease in 1937 and suggested a possible infectious aetiology. The pathogenesis of this condition still remains unclear although it is likely that infection acts as a trigger in genetically susceptible individuals. We report a patient with unusual cutaneous manifestations of Behcet's disease and antineutrophil cytoplasmic antibodies (ANCA) directed against the cytotoxic protein, bactericidal/permeability-increasing protein (BPI). This is the first report of Behcet's disease associated with this autoantibody.
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