J R Soc Med 2002;95:227-230
doi:10.1258/jrsm.95.5.227
© 2002 Royal Society of Medicine
The hypocretin/orexin system
I O Ebrahim MRCPsych
R S Howard MD FRCP 1
M D Kopelman PhD FRCPsych
M K Sharief MD 1
A J Williams FRCP 2
Department of Psychiatry, Lane Fox Unit, St Thomas' Hospital, Lambeth
Palace Road, London SE1 7EH, UK
1 Department of Neurology, Lane Fox Unit, St Thomas' Hospital, Lambeth Palace
Road, London SE1 7EH, UK
2 Sleep Disorders Centre, Lane Fox Unit, St Thomas' Hospital, Lambeth Palace
Road, London SE1 7EH, UK

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Figure 1. Projections of the hypocretin (orexin) system (A), to cholinergic
neurons, reticular formation and spinal cord; (B), to thalamus and basal
ganglia; (C), to basal forebrain; (D), to amygdala and dopaminergic neurons
including suprachiasmatic nucleus; (E), to locus coeruleus.
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