JRSM > Volume 95, Number 8 > Pp. 391-397

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Targeting the renin-angiotensin system in patients with renal disease

Mark A J Devonald BSc MRCP     Fiona E Karet PhD FRCP  

Departments of Medical Genetics and Nephrology, University of Cambridge, Cambridge, UK

View larger version (15K): [in a new window]   Figure 1. Schematic representation of renin-angiotensin-aldosterone. Agents providing pharmacological blockade are shown in italics. ACEI-angiotensin converting-enzyme inhibitor; ARB=angiotensin II receptor blocker; NSAID=non-steroidal anti-inflammatory drug; AI=angiotensin I; AII=angiotensin II; AT1 and AT2=type 1 and type 2 angiotensin II receptors respectively

 

View larger version (23K): [in a new window]   Figure 2. Possible treatment algorithm for patients with proteinuria. See text for explanation of target BPs. Broken arrows indicate points of particular caution. ACEI=angiotensin converting-enzyme inhibitor; ARB=angiotensin II receptor blocker; RAS=renal artery stenosis

 

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