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J R Soc Med 2004;97:103-110
doi:10.1258/jrsm.97.3.103
© 2004 Royal Society of Medicine

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The epidemic of asthma and allergy

Stephen T Holgate DSc FRCP  

Respiratory Cell & Molecular Biology Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK



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  		Figure 1. Henry Hyde Salter (1823–1871)

 


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  		Figure 2. Plate from Salter's Treatise (1860) illustrating the different causes of airflow obstruction

 


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  		Figure 3. Typical dose–response curves in normal and asthmatic individuals on aerosol bronchial provocation with increasing concentrations of methacholine

 


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  		Figure 4. The rising trends in asthma in different countries. The paired prevalence rates in each country were obtained with the same instruments

 


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  		Figure 5. Charles Harrison Blackley (1820–1900)

 


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  		Figure 6. The role of cytokines in directing the balance between T lymphocyte subsets. Th2-like T cells orchestrate the inflammatory response of asthma and allergy. T reg and Th3 inhibit both Th1 and Th2 responses

 


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  		Figure 7. The inhibitory effect of the anti-human IgE monoclonal antibody omalizumab on the allergic cascade

 


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  		Figure 8. Positional cloning strategy used to identify the novel asthma gene ADAM 33

 

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