JRSM >
Volume 96, Number 12 >
Pp. 592-594
General Infirmary at Leeds, LS1 3EX, UK
Correspondence to: Dr S Baron E-mail: Susannah.baron{at}ntlworld.com
The incidence of malignant melanoma continues to rise in many parts of the world. A seven-point checklist for moles is useful in identifying lesions that need to be excised. The three major signs are change in shape, change in size and change in colour; the four minor signs are over 7 mm in diameter, inflammation, crusting or bleeding and minor irritation or itch. Lesions with any major signs or three minor signs are suspicious of melanoma.1 Unfortunately malignant melanoma can present atypically.
CASE HISTORIES
Case 1
A woman of 40 sought advice about an erythematous scaly plaque on her left
arm, 0.66x.4 cm, which had appeared 3 years earlier
(Figure 1). The lesion had
gradually increased in size and become more erythematous over the preceding
three months. She had experienced blistering sunburn in childhood but there
was no family history of skin cancer. The differential diagnosis was Bowen's
disease (intraepithelial carcinoma) or an irritated seborrhoeic wart, but a
punch biopsy showed in-situ melanoma. The melanoma was excised with a
5 mm margin and histological examination confirmed lack of dermal invasion.
The patient was apparently disease-free twelve months later.
|
CASE 2
A woman aged 79 had first noticed the lesion on her cheek 2 years before,
after a minor trauma. It had gradually enlarged. On examination she had an
infiltrated plaque with a pearly edge; the diameter was about 3.3 cm but the
edges were indistinct. Directly below her eye were two pigmented macules and
there were several pigmented nodules within the plaque
(Figure 2). The clinical
diagnosis was a pigmented basal cell carcinoma but urgent biopsy revealed the
lesion to be a superficial spreading malignant melanoma with both vertical and
horizontal growth phases. The maximum thickness of the tumour on biopsy was
4.2 mm. The melanoma was widely excised by the plastic surgeons and the area
was reconstructed with a skin graft. On histological examination the Breslow
thickness was 6.1 mm. There were no signs of recurrent disease eighteen months
later.
|
CASE 3
A woman of 50 had 3 years earlier noticed a raised skin-coloured nodule on
her right lower shin, which was diagnosed by her general practitioner as a
dermatofibroma. In the past twelve months it had increased in size and bled,
spontaneously, prompting a referral to the dermatology department. On
examination the lesion was domed, flesh coloured, and firm, 1 cm in diameter,
with a small area of irregular brown pigmentation around one lateral border
(Figure 3). Because of the
macular pigmentation an incisional biopsy was performed, which was reported as
showing a benign intradermal naevus. The appearance remained of clinical
concern, so the lesion was excised by the plastic surgeons in a procedure
requiring a full-thickness skin graft. Histological examination of the entire
specimen showed a melanoma in vertical growth phase with a Breslow thickness
of 2.5 mm, extending to Clark's level 4. Unfortunately five months after
excision she developed enlarged inguinal lymph nodes, positive for metastatic
melanoma. She entered a clinical trial of interferon-alpha.
|
CASE 4
At age 41 a woman was referred by her general practitioner with an
enlarging, discharging ulcerated lesion at the base of her right third toe; it
had appeared six months earlier after a sandfly bite in Belize
(Figure 4). The history and
appearance was suggestive of cutaneous leishmaniasis and a biopsy was taken.
This showed invasive malignant melanoma with a Breslow thickness of 4 mm. The
melanoma was widely excised with 2 cm margins and the area was reconstructed
with a split skin graft. Histological examination confirmed a superficial
spreading malignant melanoma with a predominant ulcerated nodular component of
maximum Breslow thickness 4.9 mm (Clark's level 5). A wider excision was then
performed with amputation of the third and fourth toes. A year later, melanoma
was found in an enlarged right inguinal lymph node and had metastasized to
lungs and liver. Despite chemotherapy she died two months later.
|
COMMENT
Early detection of malignant melanoma is essential since survival prospects are strongly related to tumour (Breslow) thickness at the time of diagnosis.2 The Breslow thickness, measured on histological examination, is the distance between the overlying epidermal granular layer and the deepest invasive area of the primary lesion.3 For lesions of Breslow thickness <1 mm the recommended excision margin is 1 cm and 5-year survival is 95–100%. For Breslow thickness >4 mm the recommended margin is 2–3 cm and 5-year survival is about 50%. The levels of invasion into the dermis introduced by Clark et al.4 are a similar prognostic indicator related to penetration by the primary lesion, level 5 signifying invasion into fat.
About 2% of all melanomas are amelanotic, though on close inspection most amelanotic tumours do show pigmentation of the adjacent skin, as in case 3. Amelanotic melanoma is the subtype most often reported as simulating other cutaneous lesions, but even pigmented melanomas are commonly misdiagnosed—especially as melanocytic naevus, basal cell carcinoma, seborrhoeic keratosis or lentigo.5
In a study comparing the ability of general practitioners and dermatologists to discriminate pigmented lesions the general practitioners made an exact diagnosis of melanoma in 50% of the cases compared with the dermatologists' 84%.6 Any changing or atypical mole or non-healing skin lesion should be referred urgently to a dermatologist or to a surgeon with a special interest in pigmented lesions.
REFERENCES
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
